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Zantac & reg; clinically proven that this product can relieve heartburn symptoms in as little as 30 minutes to 12 hours. Pfizer's OTC is not designed to relieve heartburn immediately and requires a 14-day regimen to control frequent heartburn. Prilosec OTC is a registered trademark of Procter & Gamble, Inc. Does not include chews. Zantac – No medicine can relieve heartburn faster! Their heartburn comparison chart will help you understand how each OTC product works, so you can choose the product that suits you. It may take 1 to 4 days for it to fully take effect. The United States suffers from heartburn, of which more than 55 million people experience heartburn at night. This comparison chart will help guide you in choosing the right product for your heartburn type. This grouping prevented him from examining his stomach and esophagus for bleeding ulcers.